Description

3-Ethyl-3-Methyl-3H-Diazirine is a highly specialized, small-ring diazirine compound valued for its unique photolabile properties. It serves as a critical photoaffinity labeling reagent and a versatile precursor in advanced organic synthesis, enabling the study of biomolecular interactions and the construction of complex molecular architectures. This chemical is essential for researchers and developers in pharmaceutical discovery, agrochemical research, and materials science who require precise, light-activated crosslinking agents.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent tagging of biological targets (e.g., proteins, enzymes, receptors) upon UV irradiation to map binding sites and study biomolecular interactions in drug discovery.
• Chemical Biology Probes: Used to synthesize photoactivatable crosslinkers and probes for proteomics and genomics research.
• Advanced Organic Synthesis: Acts as a precursor for generating highly reactive carbene intermediates under mild photolytic conditions for C-H insertion and cyclopropanation reactions.
• Polymer & Materials Science: Employed in the surface functionalization of polymers and the development of photo-crosslinkable materials and hydrogels.
• Agrochemical Research: Utilized in the design and study of novel active ingredients through photoaffinity labeling techniques.

Basic Information

Product Name	3-Ethyl-3-Methyl-3H-Diazirine
CAS No.	18501-91-2
Molecular Formula	C5H10N2
Molecular Weight	98.15 g/mol
Synonyms	3-Ethyl-3-methyldiaziridine; 3-Ethyl-3-methyl-δ2-diazirine; 3H-Diazirine, 3-ethyl-3-methyl-; Diaziridine, 3-ethyl-3-methyl-; 3-Methyl-3-ethyldiaziridine; Photoaffinity Labeling Reagent 3E3M; EMD (abbreviation); 3-Ethyl-3-methyl-dihydrodiazirene
EINECS	Contact for details

Quality Control

Our 3-Ethyl-3-Methyl-3H-Diazirine is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive photochemical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant quality management standards to support research and development in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at recommended temperatures (typically 2-8°C or as specified on the label). Due to its highly volatile and light-sensitive nature, minimize exposure to ambient conditions and handle under an inert atmosphere when appropriate for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC or HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.