Description

1-Bromo-2-Hexyne is a versatile halogenated alkyne building block, essential for advanced organic synthesis. Its unique structure, featuring both a bromine atom and a terminal alkyne group, makes it a critical reagent for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. This high-purity intermediate is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of potential drug candidates, particularly for introducing alkyne functionalities for "click chemistry" applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides that require specific halogenated alkyne motifs.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polymers, dendrimers, and advanced materials with tailored properties.
• Organic Synthesis & Research: A fundamental building block for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand & Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for labeling biomolecules in diagnostic and research applications.

Basic Information

Item	Detail
Product Name	1-Bromo-2-Hexyne
CAS No.	18495-25-5
Molecular Formula	C6H9Br
Molecular Weight	161.04 g/mol
Synonyms	1-Bromo-2-hexyne; 2-Hexyn-1-yl bromide; Bromo-2-hexyne; 1-Bromohex-2-yne; Bromohex-2-yne; 2-Hexyne, 1-bromo-; 1-Bromo-2-hexin (German); 1-ブロモ-2-ヘキシン (Japanese)
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Hexyne is manufactured under stringent quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed when not in use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Density (at 20°C)	~1.30 g/mL
Refractive Index (n20D)	~1.48
Related Substances (GC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.