Description

3,4-Dichloroisothiazole-5-carbonitrile is a high-value, multi-functional heterocyclic building block and key synthetic intermediate. This compound is prized for its reactive dichloro and cyano substituents, which enable diverse chemical transformations and the construction of complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the agrochemical and pharmaceutical sectors for the development of novel active ingredients and fine chemicals.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of novel fungicides, herbicides, and insecticides, leveraging the isothiazole core for biological activity.
• Pharmaceutical Building Block: Used in medicinal chemistry for constructing drug candidates, particularly those targeting infectious diseases or requiring specific heterocyclic pharmacophores.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and functional materials with specific electronic or structural properties.
• Dye and Pigment Synthesis: Employed in the production of specialized dyes and organic pigments where the isothiazole ring contributes to color fastness and stability.
• Cross-Coupling Reactions: The chlorine atoms make it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.
• Nucleophilic Substitution Chemistry: The activated chlorines allow for sequential substitution with various nucleophiles (amines, alkoxides, thiols) to generate diverse isothiazole libraries.

Basic Information

Product Name	3,4-Dichloroisothiazole-5-Carbonitrile
CAS No.	18480-52-9
Molecular Formula	C4Cl2N2S
Molecular Weight	178.99 g/mol
Synonyms	5-Cyano-3,4-dichloroisothiazole; 3,4-Dichloro-1,2-thiazole-5-carbonitrile; 3,4-Dichloro-5-cyanoisothiazole; 3,4-Dichloroisothiazole-5-carbonitrile; Isothiazole-5-carbonitrile, 3,4-dichloro-; 3,4-Dichloro-δ2-1,2-thiazoline-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 3,4-Dichloroisothiazole-5-carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.