Description

Bis(Trimethylsilyl) Malonate is a versatile organosilicon reagent primarily used as a protected malonate synthon in organic synthesis. Its core value lies in enabling efficient carbon-carbon bond formation and functional group manipulation under mild conditions, which is critical for constructing complex molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediates: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing malonate or β-ketoester moieties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require malonate-derived structures.
• Peptide Mimetics & Drug Discovery: Facilitates the introduction of the malonyl group into peptide chains and small molecule libraries for medicinal chemistry research.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers, coatings, and silicon-containing hybrid materials.
• Fine Chemical Synthesis: Employed in Knoevenagel condensations, Michael additions, and other C-C bond-forming reactions to create complex organic molecules.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups effectively protect the malonate dicarboxyl function, allowing selective reactions at other sites on the molecule.

Basic Information

Product Name	Bis(Trimethylsilyl) Malonate
CAS No.	18457-04-0
Molecular Formula	C11H24O4Si2
Molecular Weight	276.48 g/mol
Synonyms	Malonic Acid Bis(trimethylsilyl) Ester; Propanedioic Acid, Bis(trimethylsilyl) Ester; Bis(TMS) Malonate; Di(trimethylsilyl) Malonate; TMS Malonate; 1,3-Bis(trimethylsilyloxy)-1,3-dioxopropane; Malonic Acid Di(trimethylsilyl) Ester; Dimethylmalonate Bis(trimethylsilyl) Acetal (common misnomer)
EINECS	242-329-7

Quality Control

Our Bis(Trimethylsilyl) Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available for every shipment. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.