Description

Cucurbitacin E is a highly bioactive tetracyclic triterpenoid compound, a member of the cucurbitacin family known for its potent biological effects. Its primary value lies in its role as a critical reference standard and active research compound for investigating anti-inflammatory, anti-cancer, and hepatoprotective mechanisms. This compound is essential for pharmaceutical R&D laboratories, nutraceutical formulators, and academic institutions focused on natural product chemistry and drug discovery.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate for studying anti-cancer, anti-inflammatory, and hepatoprotective activities.
• Biochemical & Pharmacological Studies: Used as a selective inhibitor of the JAK/STAT and NF-κB signaling pathways in cell-based assays and animal models.
• Natural Product Standardization: Acts as a certified reference material for the quality control and standardization of herbal extracts from Cucurbitaceae plants (e.g., bitter melon, wild cucumber).
• Academic & Institutional Research: Employed in universities and research institutes for investigating the structure-activity relationships of triterpenoids and their therapeutic potential.
• Preclinical Drug Discovery: Utilized in lead optimization and mechanism-of-action studies for novel oncology and immunology therapeutics.
• Analytical Chemistry: Functions as a high-purity calibration standard for HPLC, LC-MS, and NMR analysis in method development and compound identification.

Basic Information

Product Name	Cucurbitacin E
CAS No.	18444-66-1
Molecular Formula	C32H44O8
Molecular Weight	556.70 g/mol
Synonyms	α-Elaterin; Elatericin; Cucurbitacin E; Cucurbitacine E; (23E)-25-Acetoxy-3β,16α,20-trihydroxy-9β-methyl-19-norlanosta-5,23-diene-11,22-dione; 3β,16α,20-Trihydroxy-9β-methyl-19-nor-5α-lanosta-23-ene-11,22-dione 25-acetate; NSC 106400
EINECS	242-325-9

Quality Control

Our Cucurbitacin E is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis to ensure it meets high-purity research-grade specifications. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant test results is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. For long-term storage, consider storing at 2-8°C under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.