Description

2-Hydroxy-3-Butynoic Acid Ethyl Ester is a versatile bifunctional building block containing both a hydroxyl group and an alkyne moiety within its ester structure. This unique molecular architecture makes it a valuable intermediate for the synthesis of complex molecules in advanced research and industrial chemistry. It is particularly sought after by pharmaceutical, agrochemical, and specialty chemical manufacturers for constructing heterocycles, bioactive compounds, and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in constructing acetylene-linked molecular scaffolds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require alkyne functionality.
• Click Chemistry Reagent: Serves as a precursor for Huisgen cycloaddition (azide-alkyne click chemistry) to create triazole linkages in polymer and bioconjugation chemistry.
• Material Science: Building block for specialty polymers, dendrimers, and liquid crystals where the alkyne group enables further functionalization.
• Organic Synthesis: A versatile reagent for Sonogashira coupling and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing complex ester-based aroma compounds.

Basic Information

Product Name	2-Hydroxy-3-Butynoic Acid Ethyl Ester
CAS No.	18418-08-1
Molecular Formula	C6H8O3
Molecular Weight	128.13 g/mol
Synonyms	Ethyl 2-Hydroxy-3-butynoate; Ethyl 2-Hydroxybut-3-ynoate; 3-Butynoic acid, 2-hydroxy-, ethyl ester; 2-Hydroxy-3-butynoic acid ethyl ester; But-3-ynoic acid, 2-hydroxy-, ethyl ester; Ethyl (2-hydroxybut-3-ynoate); Acetylene glycolic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Butynoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents and bases. The container should be kept tightly sealed when not in use to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.