Description

3-Bromobutyric Acid Trimethylsilyl Ester is a versatile organosilicon reagent featuring a reactive bromoalkyl group. This compound is a valuable synthetic intermediate, prized for its dual functionality which allows for selective transformations in complex molecule assembly. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing carbon-carbon bonds and introducing functional handles.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing butyric acid derivatives or halogenated side chains.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators requiring specific halogenated carboxylic acid motifs.
• Organic Synthesis Reagent: Serves as a protected form of 3-bromobutyric acid for nucleophilic substitution reactions, Grignard reagent preparation, and palladium-catalyzed cross-couplings.
• Material Science Precursor: Employed in the development of specialty polymers, liquid crystals, and organic semiconductors where the silyl ester group aids in purification and volatility.
• Chemical Research & Development: Essential tool in medicinal chemistry for analog synthesis and structure-activity relationship (SAR) studies.
• Custom Synthesis Projects: Provides a flexible starting point for contract research organizations (CROs) and fine chemical manufacturers undertaking bespoke synthesis.

Basic Information

Product Name	3-Bromobutyric Acid Trimethylsilyl Ester
CAS No.	18301-67-2
Molecular Formula	C7H15BrO2Si
Molecular Weight	239.18 g/mol
Synonyms	Trimethylsilyl 3-bromobutyrate; 3-Bromobutyric Acid TMS Ester; Butanoic acid, 3-bromo-, trimethylsilyl ester; TMS 3-Bromobutyrate; 3-Bromobutanoic Acid Trimethylsilyl Ester; (3-Bromobutanoyloxy)trimethylsilane; Silicon TMS ester of 3-bromobutyric acid
EINECS	Contact for details

Quality Control

Our 3-Bromobutyric Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.