Description

Trimethylsilylpyrazole is a versatile organosilicon reagent featuring a reactive pyrazole ring protected by a trimethylsilyl (TMS) group. This compound is a critical building block in organic synthesis, valued for its role as a silylating agent and a protected intermediate for the introduction of the pyrazole moiety. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing pyrazole cores, such as kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of modern pesticides and herbicides where the pyrazole structure imparts specific biological activity.
• Silylation Reagent: Protects hydroxyl or other active hydrogen groups in sensitive synthetic pathways, facilitating multi-step synthesis.
• Ligand Precursor: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel organic semiconductors and functional polymers.
• Custom Synthesis: A valuable reagent for contract research organizations (CROs) and fine chemical manufacturers engaged in bespoke molecule production.

Basic Information

Product Name	Trimethylsilylpyrazole
CAS No.	18276-53-4
Molecular Formula	C6H12N2Si
Molecular Weight	140.26 g/mol
Synonyms	1-(Trimethylsilyl)-1H-pyrazole; 1H-Pyrazole, 1-(trimethylsilyl)-; 1-Trimethylsilylpyrazole; TMS-Pyrazole; Pyrazole, 1-trimethylsilyl-; 1-TMS-pyrazole; (Trimethylsilyl)pyrazole; Pyrazole, trimethylsilyl-
EINECS	Contact for details

Quality Control

Our Trimethylsilylpyrazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat and open flames. Keep under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.