Description

Trimethylsilyl Crotonate is a versatile organosilicon reagent primarily used as a silylating agent and a protected synthon in advanced organic synthesis. Its value lies in its ability to introduce the trimethylsilyl (TMS) group, which can modify reactivity, enhance volatility for analysis, or serve as a temporary protecting group for carboxylic acids. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key building block and protecting group reagent in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Employed in the manufacture of advanced pesticides, herbicides, and plant growth regulators where specific functional group protection is required.
• Derivatization Agent for GC/MS: Serves as a silylation reagent to increase the volatility and thermal stability of polar organic compounds (e.g., carboxylic acids, alcohols) for more accurate gas chromatography-mass spectrometry (GC/MS) analysis.
• Polymer & Material Science: Acts as a monomer or modifying agent in the synthesis of specialized silicone-based polymers and hybrid organic-inorganic materials.
• Organic Synthesis Reagent: Facilitates various reactions, including Horner-Wadsworth-Emmons olefinations and other carbon-carbon bond-forming processes, as a stabilized carbanion equivalent.
• Flavor & Fragrance Chemistry: Utilized in the synthesis of specific ester compounds that contribute to complex aroma and flavor profiles.

Basic Information

Product Name	Trimethylsilyl Crotonate
CAS No.	18269-64-2
Molecular Formula	C7H14O2Si
Molecular Weight	158.27 g/mol
Synonyms	Crotonic Acid Trimethylsilyl Ester; (E)-But-2-enoic Acid Trimethylsilyl Ester; Trimethylsilyl (E)-But-2-enoate; TMS Crotonate; Trimethyl(oxobut-2-en-2-yloxy)silane; 2-Butenoic Acid, Trimethylsilyl Ester; (E)-Trimethylsilyl Crotonate
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Crotonate is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and kept away from heat, sparks, and open flames. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Isomeric Purity (E-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.