Description

cis-Bicyclo(3.3.0)Octane-2-Carboxylic acid is a specialized, high-purity bicyclic carboxylic acid derivative with a unique fused ring structure. This compound serves as a critical advanced pharmaceutical intermediate and a versatile chiral building block for complex organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce constrained, three-dimensional geometry into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and cardiovascular diseases.
• Chiral Auxiliary & Ligand Synthesis: Used to construct sophisticated chiral ligands for asymmetric catalysis and as a core scaffold for chiral auxiliaries.
• Agrochemical Research: Building block for developing new generation herbicides and fungicides with enhanced stereoselective activity.
• Material Science: Monomer or additive for creating polymers with specific rigid backbone structures, influencing material properties like thermal stability.
• Flavor & Fragrance Chemistry: Intermediate for synthesizing musky or amber-type odorants with complex stereochemistry.
• Academic & R&D: Valuable reagent for methodological studies in organic synthesis, including ring-forming reactions and stereochemistry research.

Basic Information

Product Name	cis-Bicyclo(3.3.0)Octane-2-Carboxylic Acid
CAS No.	18209-43-3
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	(1R,2S,5R)-Bicyclo[3.3.0]octane-2-carboxylic acid; cis-Bicyclo[3.3.0]octane-2-carboxylic acid; (1R,2S,5R)-Octahydro-1H-cyclopenta[c]furan-1-carboxylic acid; Bicyclo(3.3.0)octane-2-carboxylic acid, cis-; 2-Bicyclo[3.3.0]octanecarboxylic acid, (1R,2S,5R)-rel-; rel-(1R,2S,5R)-Bicyclo[3.3.0]octane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our cis-Bicyclo(3.3.0)Octane-2-Carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical customers and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.