Description

(+)-8-[(3,3-Dimethyloxiran-2-Yl)Methyl]-5,7-Dimethoxy-2H-1-Benzopyran-2-One is a high-purity, optically active coumarin derivative characterized by its unique epoxide and methoxy functional groups. This compound matters as a versatile and valuable chiral building block for the synthesis of complex organic molecules, particularly in the development of pharmaceuticals and bioactive natural product analogs. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates, especially those targeting specific biological pathways.
• Asymmetric Synthesis: Utilized as a building block for constructing complex, enantiomerically pure molecules due to its defined stereochemistry at the epoxide center.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Natural Product Analog Synthesis: Used to synthesize analogs of naturally occurring coumarin derivatives for biological evaluation.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with specific modes of action.
• Chemical Biology Probes: Can be functionalized to create molecular probes for studying enzyme mechanisms or cellular processes.

Basic Information

Product Name	(+)-8-[(3,3-Dimethyloxiran-2-Yl)Methyl]-5,7-Dimethoxy-2H-1-Benzopyran-2-One
CAS No.	18196-01-5
Molecular Formula	C₁₇H₂₀O₅
Molecular Weight	304.34 g/mol
Synonyms	(+)-8-(3,3-Dimethyloxiran-2-ylmethyl)-5,7-dimethoxy-2H-chromen-2-one; (2R)-8-[(3,3-Dimethyloxiran-2-yl)methyl]-5,7-dimethoxy-2H-chromen-2-one; (R)-8-(3,3-Dimethyloxiran-2-ylmethyl)-5,7-dimethoxycoumarin; 5,7-Dimethoxy-8-[(3,3-dimethyloxiran-2-yl)methyl]coumarin; (R)-5,7-Dimethoxy-8-(3,3-dimethyloxiran-2-ylmethyl)coumarin; (R)-Epoxyauraptene; Auraptene epoxide (enantiomer); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (+)-8-[(3,3-Dimethyloxiran-2-Yl)Methyl]-5,7-Dimethoxy-2H-1-Benzopyran-2-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.