Description

1-Cbz-[1,4]Diazepan-5-One is a high-purity, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and specialized materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of diazepane and piperazine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide secondary structures, enhancing metabolic stability and bioavailability in drug design.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring the introduction of a protected 1,4-diazepan-5-one moiety.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, or insecticides with specific biological activity.
• Academic & Institutional Research: Used in universities and research institutes for methodological development and exploring new synthetic pathways involving nitrogen heterocycles.

Basic Information

Product Name	1-Cbz-[1,4]Diazepan-5-One
CAS No.	18158-16-2
Molecular Formula	C₁₄H₁₈N₂O₃
Molecular Weight	262.31 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-1,4-diazepan-5-one; 1-Carbobenzyloxy-1,4-diazepan-5-one; 1-Cbz-1,4-diazepan-5-one; 5-Oxo-1,4-diazepane-1-carboxylic acid benzyl ester; Benzyl 5-oxo-1,4-diazepane-1-carboxylate; N-Cbz-1,4-diazepan-5-one; 1,4-Diazepan-5-one, 1-[(phenylmethoxy)carbonyl]-; NSC 328426
EINECS	Contact for details

Quality Control

Our 1-Cbz-[1,4]Diazepan-5-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.