Description

(Trimethylsilyl)Diazomethane CAS NO 18107-18-1 is a versatile organosilicon reagent primarily used as a safe and efficient methylating and homologating agent. It serves as a stable, non-explosive alternative to hazardous diazomethane, offering significant advantages in laboratory safety and handling. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as esterification, homologation of carbonyl compounds, and the synthesis of heterocycles.

Application

• Methylation Agent: Safe esterification of carboxylic acids to methyl esters under mild conditions.
• Homologation Reagent: Conversion of aldehydes and ketones into homologated carbonyl compounds (e.g., Arndt-Eistert synthesis).
• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules.
• Agrochemical Synthesis: Used in the production of pesticides, herbicides, and plant growth regulators.
• Material Science: Precursor for modifying surfaces and synthesizing specialized silicon-containing polymers.
• Analytical Chemistry: Derivatization agent for gas chromatography (GC) and mass spectrometry (MS) sample preparation.
• Diazomethane Substitute: Critical for all synthetic applications requiring diazomethane but demanding enhanced operational safety.
• Research & Development: Valuable tool in organic synthesis for constructing C-C and C-Si bonds in novel compound libraries.

Basic Information

Product Name	(Trimethylsilyl)Diazomethane
CAS No.	18107-18-1
Molecular Formula	C4H10N2Si
Molecular Weight	114.22 g/mol
Synonyms	Trimethylsilyldiazomethane; TMS-Diazomethane; Diazomethyl(trimethyl)silane; (Diazomethyl)trimethylsilane; Trimethylsilyl diazomethane; (Trimethylsilyl)diazomethane solution; N-(Trimethylsilyl)diazomethane; TMSCHN2
EINECS	Contact for details

Quality Control

Our (Trimethylsilyl)Diazomethane is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Due to its highly volatile and strictly light-sensitive nature, it is recommended to store at 2-8°C for extended stability. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Assay (GC or NMR)	≥ 95.0%
Purity (GC)	≥ 98.0%
Solvent (Typical)	Hexane or Diethyl ether
Concentration	0.5 - 2.0 M (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.