Description

2-Methyl-5-Trifluoroacetylthiophene is a high-value fluorinated heterocyclic building block, specifically a thiophene derivative functionalized with a trifluoroacetyl group. This compound is prized for its unique reactivity profile, offering a versatile synthon for the introduction of trifluoromethylated motifs into complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the synthesis of advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups known to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group can improve biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for creating fluorinated polymers, liquid crystals, and organic electronic materials with tailored properties.
• Medicinal Chemistry & Drug Discovery: Employed in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore novel chemical space.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the incorporation of fluorinated thiophene scaffolds.
• Chemical Research & Development: Utilized in academic and industrial R&D for developing new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Methyl-5-Trifluoroacetylthiophene
CAS No.	18087-61-1
Molecular Formula	C7H5F3OS
Molecular Weight	194.17 g/mol
Synonyms	1-(5-Methyl-2-thienyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-methyl-2-thienyl)ethanone; 5-Methyl-2-thenoyltrifluoride; 5-Methyl-2-thienyl trifluoromethyl ketone; 2-Acetyl-5-methylthiophene, trifluoro derivative; 2-Methyl-5-(trifluoroacetyl)thiophene; 2-Methyl-5-trifluoroacetylthiophene; 5-Methyl-2-(trifluoroacetyl)thiophene
EINECS	Contact for details

Quality Control

Our 2-Methyl-5-Trifluoroacetylthiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle and store with appropriate chemical safety precautions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.