Description

Methyl 1-tert-Butyl-2-Azetidinecarboxylate is a versatile azetidine derivative, a crucial nitrogen-containing heterocyclic building block in advanced organic synthesis. Its value lies in its role as a protected precursor for introducing the constrained azetidine ring system, which is increasingly important in medicinal chemistry for modulating the physicochemical properties of drug candidates. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates containing the azetidine moiety, which is prized for improving metabolic stability, solubility, and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate nitrogen heterocycles for enhanced activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and functional materials with unique properties derived from the azetidine ring.
• Academic & Contract Research: A valuable reagent for methodological studies and library synthesis in academic institutions and CROs (Contract Research Organizations).

Basic Information

Product Name	Methyl 1-tert-Butyl-2-Azetidinecarboxylate
CAS No.	18085-35-3
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	1-(tert-Butyl) 2-Methyl Azetidine-1,2-dicarboxylate; 2-Azetidinecarboxylic acid, 1-(1,1-dimethylethyl)-, methyl ester; Methyl N-Boc-2-azetidinecarboxylate; 1-Boc-2-azetidinecarboxylic acid methyl ester; N-Boc-2-Azetidinecarboxylic Acid Methyl Ester; 1-tert-Butoxycarbonyl-2-azetidinecarboxylic Acid Methyl Ester; Azetidine-2-carboxylic acid, 1-Boc-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-tert-Butyl-2-Azetidinecarboxylate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting the exact specifications for your records and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.