Description

1,4,7,10-Tetrabenzyl-1,4,7,10-tetraazacyclododecane is a key benzyl-protected intermediate in the synthesis of sophisticated macrocyclic ligands. This compound is essential for researchers and manufacturers developing high-performance chelating agents, particularly for medical imaging and catalysis. It is primarily used by the pharmaceutical, chemical research, and specialty materials industries to create functionalized cyclen derivatives for metal complexation.

Application

• Pharmaceutical Intermediate: Critical precursor for synthesizing MRI contrast agent chelators like DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives.
• Coordination Chemistry Research: Serves as a protected starting material for developing novel macrocyclic ligands with tailored properties for specific metal ions (e.g., lanthanides, transition metals).
• Catalyst Development: Used to create metal complexes that act as catalysts in organic synthesis and polymerization reactions.
• Radiopharmaceuticals: Intermediate in the production of bifunctional chelators for labeling peptides and antibodies with diagnostic or therapeutic radionuclides.
• Material Science: Building block for functionalized materials, such as metal-organic frameworks (MOFs) or sensors, that require precise macrocyclic architectures.

Basic Information

Product Name	1,4,7,10-Tetrabenzyl-1,4,7,10-tetraazacyclododecane
CAS No.	18084-64-5
Molecular Formula	C44H48N4
Molecular Weight	632.88 g/mol
Synonyms	TBz-Cyclen; 1,4,7,10-Tetrabenzyl-cyclen; Tetrabenzyl-1,4,7,10-tetraazacyclododecane; 1,4,7,10-Tetraazacyclododecane, 1,4,7,10-tetrakis(phenylmethyl)-; 1,4,7,10-Tetrabenzyl-1,4,7,10-tetraazacyclododecane; Cyclen tetrabenzyl derivative; 1,4,7,10-Tetrabenzyl-DOTA precursor
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetrabenzyl-1,4,7,10-tetraazacyclododecane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and mass spectrometry data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.