Description

(+)-9-(1,3-Benzodioxol-5-Yl)-3A,4-Dihydro-6,7-Dimethoxynaphtho[2,3-C]Furan-1(3H)-One is a high-purity, optically active benzodioxole-fused naphthofuranone derivative, serving as a critical chiral building block and reference standard in advanced organic synthesis. Its complex polycyclic structure and defined stereochemistry make it invaluable for the development of novel pharmacologically active compounds. This specialty chemical is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or advanced intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Natural Product Synthesis: A valuable intermediate for the total or semi-synthesis of complex natural products containing benzodioxole and naphthofuranone motifs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(+)-9-(1,3-Benzodioxol-5-Yl)-3A,4-Dihydro-6,7-Dimethoxynaphtho[2,3-C]Furan-1(3H)-One
CAS No.	17990-72-6
Molecular Formula	C23H20O6
Molecular Weight	392.41 g/mol
Synonyms	(+)-9-(1,3-Benzodioxol-5-yl)-3a,4-dihydro-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one; (3aS,9R)-9-(1,3-Benzodioxol-5-yl)-3a,4-dihydro-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one; (R)-9-(Benzo[d][1,3]dioxol-5-yl)-3a,4-dihydro-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one; (3aS,9R)-9-(Benzo[d][1,3]dioxol-5-yl)-3a,4-dihydro-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one; (R)-9-(1,3-Benzodioxol-5-yl)-3a,4-dihydro-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one; Naphtho[2,3-c]furan-1(3H)-one derivative
EINECS	Contact for details

Quality Control

Our production of this specialty intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, essential for research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. While produced under GMP-like conditions suitable for non-clinical research, specifications can be tailored to meet specific project requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.