Description

Triethylphosphonodifluoroacetate is a high-value organophosphorus reagent featuring a difluoroacetate moiety. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in the development of pharmaceuticals and agrochemicals. Industries that require advanced fluorinated intermediates, such as pharmaceutical R&D, agrochemical manufacturing, and specialty chemical synthesis, are the primary users of this product.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other biologically active compounds.
• Agrochemical Synthesis: Used in the production of novel, fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity and stability.
• Material Science: Serves as a monomer or modifier in the creation of specialty polymers and coatings with unique surface properties.
• Organic Synthesis Reagent: Employed in Horner-Wadsworth-Emmons (HWE) olefination reactions to introduce difluoromethylene groups into target molecules.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on developing new fluorination methodologies and fluorinated compounds.
• Ligand and Catalyst Development: Used in the preparation of phosphonate-based ligands for metal-catalyzed reactions.

Basic Information

Product Name	Triethylphosphonodifluoroacetate
CAS No.	17843-01-5
Molecular Formula	C8H15F2O3P
Molecular Weight	228.18 g/mol
Synonyms	Diethyl (Difluoroacetoxy)methylphosphonate; (Diethoxyphosphinyl)difluoroacetic Acid Ethyl Ester; Triethyl (Difluoroacetyl)phosphonate; Ethyl Difluoro(phosphono)acetate Triethyl Ester; (Diethoxyphosphoryl)difluoroacetic Acid Ethyl Ester; Acetic acid, 2,2-difluoro-2-(triethylphosphono)-; Triethyl phosphonodifluoroacetate
EINECS	Contact for details

Quality Control

Our Triethylphosphonodifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.