Description

1-Bromo-3-Cyclobutyl-Benzene is a versatile brominated aromatic building block characterized by its cyclobutyl substituent. This compound is valued for its role as a key synthetic intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a functionalized biphenyl or aryl-cyclobutyl core.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the bromine atom serves as a handle for further functionalization.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers, leveraging its rigid aromatic-cyclobutyl structure.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions such as Suzuki, Heck, and Buchwald-Hartwig aminations to form new carbon-carbon and carbon-heteroatom bonds.
• Ligand and Catalyst Development: Utilized as a precursor for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Chemical Biology Probes: Acts as a starting material for creating tagged molecules or photoaffinity labels used in proteomics and biochemical research.

Basic Information

Product Name	1-Bromo-3-Cyclobutyl-Benzene
CAS No.	17789-13-8
Molecular Formula	C10H11Br
Molecular Weight	211.10 g/mol
Synonyms	3-Bromophenylcyclobutane; (3-Bromophenyl)cyclobutane; 3-Cyclobutylbromobenzene; m-Bromocyclobutylbenzene; 1-Bromo-3-cyclobutylbenzene; 3-Bromo-1-cyclobutylbenzene; Benzene, 1-bromo-3-cyclobutyl-; Cyclobutyl(3-bromophenyl)
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Cyclobutyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.