Description

5-Phenylbicyclo[1.1.1]pentan-5-ol is a high-value, structurally constrained bicyclic alcohol featuring a unique [1.1.1]propellane core. This compound matters as a sophisticated chemical building block and pharmacophore for advanced research and development, enabling the synthesis of novel molecular architectures with potential for enhanced biological activity and material properties. It is primarily needed by pharmaceutical R&D teams and agrochemical innovators for drug discovery, as well as by academic and industrial research chemists exploring new chemical space in medicinal chemistry and materials science.

Application

• Pharmaceutical Intermediate: A key synthon in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for creating three-dimensional, sp3-rich scaffolds to improve drug-like properties.
• Medicinal Chemistry Research: Used as a rigid, bioisosteric replacement for phenyl or other aromatic groups to modulate potency, selectivity, and metabolic stability of lead compounds.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, or insecticides that require unique steric and electronic profiles.
• Academic Research & Method Development: Employed in studies of strain-release chemistry, C–H functionalization of bicyclo[1.1.1]pentanes, and the development of new synthetic methodologies.
• Material Science Exploration: Investigated as a monomer or cross-linking agent for creating polymers with unusual thermal or mechanical properties due to its highly strained core.
• Chemical Biology Probe Development: Utilized to create tool compounds for studying protein-ligand interactions and biological pathways.

Basic Information

Product Name	5-Phenylbicyclo[1.1.1]pentan-5-ol
CAS No.	17684-73-0
Molecular Formula	C11H12O
Molecular Weight	160.21 g/mol
Synonyms	5-Phenyl-5-hydroxybicyclo[1.1.1]pentane; 5-Hydroxy-5-phenylbicyclo[1.1.1]pentane; 5-Phenylbicyclo[1.1.1]pentan-5-ol; 1-Phenyl-3-oxabicyclo[3.1.1]heptane (tautomeric form); Bicyclo[1.1.1]pentan-5-ol, 5-phenyl-; 5-Phenyl-1,3-dioxabicyclo[3.1.1]heptane (possible derivative name); [1.1.1]Propellane, 5-phenyl-5-hydroxy-
EINECS	Contact for details

Quality Control

Our 5-Phenylbicyclo[1.1.1]pentan-5-ol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider inert gas (argon/nitrogen) purging to minimize potential oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.