Description

Phorbol CAS NO 17673-25-5 is a complex organic compound belonging to the diterpene ester class, known for its potent biological activity. It serves as a critical reference standard and research chemical in the study of cellular signaling pathways, particularly protein kinase C (PKC) activation. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life sciences sectors.

Application

• Biomedical Research: As a potent activator of protein kinase C (PKC), used to study cell proliferation, differentiation, apoptosis, and tumor promotion mechanisms.
• Pharmacology & Toxicology: Employed as a reference standard in assays to investigate the effects of tumor promoters and to develop potential PKC inhibitors.
• Biochemical Reagent: Used in enzymatic studies and signal transduction research to understand the role of PKC in various disease models.
• Pharmaceutical Development: Serves as a critical tool compound in drug discovery programs targeting PKC-related pathways for cancer, inflammatory, and neurological disorders.
• Quality Control & Standardization: Utilized as an analytical reference standard (CRS) for the identification and quantification of phorbol esters in complex matrices.
• Academic Research: A key material for universities and research institutes studying natural product chemistry, molecular biology, and carcinogenesis.

Basic Information

Product Name	Phorbol
CAS No.	17673-25-5
Molecular Formula	C20H28O6
Molecular Weight	364.44 g/mol
Synonyms	Phorbol; 4,9,12-beta,13,20-Pentahydroxy-1,6-tigliadien-3-one; 1,1a,1b,4,4a,7a,7b,8,9,9a-Decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one; TPA parent alcohol; NSC 32623
EINECS	241-654-1

Quality Control

Our Phorbol is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom purity grades and analytical services are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its light-sensitive and easily oxidized nature, prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.