Description

2-Pyrrolidinecarboxamide,3,4-Dihydroxy-,trans-2,3,cis-3,4-()-(8Ci) is a high-purity, stereochemically defined heterocyclic compound, also known as trans-3,4-Dihydroxy-L-proline amide. This specialized chemical is valued for its role as a key chiral building block and intermediate in advanced organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of complex molecules, including potential drug candidates and bioactive compounds. Our supply ensures consistent quality and reliable availability for critical global R&D and production processes.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in projects targeting neurological and metabolic diseases.
• Peptidomimetics & Proline Analogue Synthesis: Used in the design and synthesis of peptidomimetics and modified peptides where the rigid, hydroxylated proline scaffold is required to influence conformation and bioactivity.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for the synthesis of chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Biochemical Research: Employed in biochemical studies as a substrate or inhibitor analogue for enzymes that interact with hydroxyproline, such as certain prolyl hydroxylases and collagen-modifying enzymes.
• Fine Chemical Synthesis: Utilized as a building block for the preparation of complex natural product analogs and other high-value specialty chemicals.

Basic Information

Product Name	2-Pyrrolidinecarboxamide,3,4-Dihydroxy-,trans-2,3,cis-3,4-()-(8Ci)
CAS No.	17663-42-2
Molecular Formula	C5H10N2O3
Molecular Weight	146.15 g/mol
Synonyms	trans-3,4-Dihydroxy-L-proline amide; (2S,3R,4R)-3,4-Dihydroxypyrrolidine-2-carboxamide; L-threo-3,4-Dihydroxyproline amide; 3,4-Dihydroxy-L-proline amide; Amide of L-threo-3,4-dihydroxyproline; (2S,3R,4R)-2-Carbamoyl-3,4-dihydroxypyrrolidine; 17663-42-2
EINECS	Contact for details

Quality Control

Every batch of our 2-Pyrrolidinecarboxamide,3,4-Dihydroxy-,trans-2,3,cis-3,4-()-(8Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for each lot upon request. Our quality commitment supports compliance in cGMP-related development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.