Description

2-((1R,2S,4R)-Bicyclo[2.2.1]Hept-5-En-2-Yl)But-3-Yn-2-Ol CAS NO 17385-45-4 is a high-purity, chiral bicyclic compound featuring both an alkene and an alkyne functional group, making it a versatile and valuable advanced pharmaceutical intermediate and building block for complex organic synthesis. Its unique stereochemistry and reactive handles are critical for constructing intricate molecular architectures with precise three-dimensional control. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS) or requiring specific stereochemistry for efficacy.
• Agrochemical Synthesis: Used as a building block for developing novel pesticides and herbicides with enhanced activity and selectivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers with tailored thermal or mechanical properties.
• Catalyst Ligand Development: The rigid bicyclic framework can be functionalized to create novel chiral ligands for asymmetric catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including cycloaddition reactions and tandem catalytic processes.
• Fine Chemical Production: Employed in the multi-step synthesis of fragrances, flavors, and other high-value specialty chemicals.

Basic Information

Product Name	2-((1R,2S,4R)-Bicyclo[2.2.1]Hept-5-En-2-Yl)But-3-Yn-2-Ol
CAS No.	17385-45-4
Molecular Formula	C₁₁H₁₄O
Molecular Weight	162.23 g/mol
Synonyms	(1R,2S,4R)-2-(1-Hydroxy-1-methyl-2-propynyl)bicyclo[2.2.1]hept-5-ene; 2-(Norborn-5-en-2-yl)but-3-yn-2-ol; (1R,2S,4R)-2-(3-Hydroxy-3-methylbut-1-yn-1-yl)bicyclo[2.2.1]hept-5-ene; exo-2-(3-Hydroxy-3-methyl-1-butynyl)-5-norbornene; Chiral Norbornene Alkyne Alcohol; Bicyclo[2.2.1]hept-5-ene-2-methanol, α-ethynyl-α-methyl-, (1R,2S,4R)-
EINECS	Contact for details

Quality Control

Every batch of our 2-((1R,2S,4R)-Bicyclo[2.2.1]Hept-5-En-2-Yl)But-3-Yn-2-Ol is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, GC, NMR, and chiral analysis. Our production adheres to cGMP guidelines where applicable, ensuring suitability for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.