Description

1-tert-Butylazetidine-3-Carboxylic Acid is a high-value, multifunctional azetidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its constrained four-membered ring structure and carboxylic acid functionality make it a versatile intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Compounds: The azetidine scaffold is incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and functional materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	1-tert-Butylazetidine-3-Carboxylic Acid
CAS No.	17358-76-8
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	3-Azetidinecarboxylic acid, 1-(1,1-dimethylethyl)-; 1-tert-Butyl-3-carboxyazetidine; 1-(tert-Butyl)azetidine-3-carboxylic acid; Azetidine-3-carboxylic acid, 1-tert-butyl derivative; 1-Boc-azetidine-3-carboxylic acid (common name); 1-(tert-Butyl)azetidine-3-carboxylic acid; 1-tert-Butylazetidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-tert-Butylazetidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data (HPLC, NMR, IR) are provided to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.