Description

2-(4-Hydroxy-Benzylidene)-Malonic Acid Diethyl Ester is a versatile organic intermediate belonging to the class of malonic ester derivatives. This compound is valued for its conjugated system and reactive functional groups, making it a key building block in synthetic organic chemistry. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex molecules, heterocycles, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly those with benzylidene or chalcone scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Acts as a building block for synthesizing dyes, pigments, and advanced organic materials.
• Academic & Industrial Research: Employed in organic synthesis methodologies, including Knoevenagel condensations and cyclization reactions, to create novel chemical entities.
• Material Science: Investigated as a monomer or precursor for polymers and functional organic materials with specific optical or electronic properties.

Basic Information

Product Name	2-(4-Hydroxy-Benzylidene)-Malonic Acid Diethyl Ester
CAS No.	17315-86-5
Molecular Formula	C₁₄H₁₆O₅
Molecular Weight	264.27 g/mol
Synonyms	Diethyl 2-[(4-hydroxyphenyl)methylene]malonate; Diethyl (4-hydroxybenzylidene)malonate; 4-Hydroxybenzylidenemalonic Acid Diethyl Ester; Ethyl (4-Hydroxybenzylidene)malonate; 2-((4-Hydroxybenzylidene))malonic Acid Diethyl Ester; (4-Hydroxybenzylidene)malonic Acid Diethyl Ester; Propanedioic acid, 2-[(4-hydroxyphenyl)methylene]-, 1,3-diethyl ester
EINECS	Contact for details

Quality Control

Our 2-(4-Hydroxy-Benzylidene)-Malonic Acid Diethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.