Description

2-(Difluoromethylene)-4,4,5-Trifluoro-5-(Trifluoromethyl)-1,3-Dioxolane is a specialized fluorinated dioxolane derivative, a high-value intermediate in advanced chemical synthesis. Its unique structure, featuring a difluoromethylene group and multiple trifluoromethyl substituents, makes it a critical building block for introducing fluorine atoms into target molecules, thereby enhancing their stability, lipophilicity, and biological activity. This compound is essential for R&D and production in the pharmaceutical and agrochemical industries, where precise fluorination is required to develop new active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: A key fluorinated synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where fluorination improves weather resistance, bioavailability, and target specificity.
• Advanced Material Precursor: Serves as a monomer or building block for specialty polymers, coatings, and electronic materials requiring high thermal stability and chemical resistance.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) to optimize electronic properties.
• Fluorinated Surfactant & Lubricant Development: Acts as an intermediate for creating high-performance, thermally stable fluorosurfactants and lubricants used in demanding industrial applications.
• Organic Synthesis & Catalysis: A versatile reagent in academic and industrial organic chemistry for constructing complex, fluorinated molecular architectures.

Basic Information

Product Name	2-(Difluoromethylene)-4,4,5-Trifluoro-5-(Trifluoromethyl)-1,3-Dioxolane
CAS No.	17256-52-9
Molecular Formula	C5F8O2
Molecular Weight	244.04 g/mol
Synonyms	2-(Difluoromethylene)-4,4,5-trifluoro-5-(trifluoromethyl)-1,3-dioxolane; Perfluoro(4-methylene-2,2-dimethyl-1,3-dioxolane); 4-Methylene-2,2-bis(trifluoromethyl)-1,3-dioxolane (alternative naming); 1,3-Dioxolane, 2-(difluoromethylene)-4,4,5-trifluoro-5-(trifluoromethyl)-; F8D; Fluorinated dioxolane derivative; PFDMD; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethylene)-4,4,5-Trifluoro-5-(Trifluoromethyl)-1,3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR (¹H, ¹⁹F), and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP standards where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature and sensitivity to fluoride/strong alkali, store in a cool, well-ventilated place at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Keep away from heat, sparks, open flames, and incompatible materials. Use appropriate explosion-proof equipment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H, ¹⁹F)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.