Description

2-Chloro-5-Methylthiophene is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its reactivity, which enables the construction of complex molecular architectures, particularly in the development of functional materials and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific thiophene-based motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the thiophene ring contributes to biological activity.
• Material Science Precursor: Serves as a monomer or building block for conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, facilitating cross-coupling and other key reactions.
• Organic Synthesis Building Block: Utilized in various name reactions (e.g., Suzuki, Stille couplings) to introduce functionalized thiophene units into more complex organic molecules.
• Research and Development (R&D): A critical reagent for medicinal chemistry and process chemistry research in both academic and industrial settings.

Basic Information

Item	Detail
Product Name	2-Chloro-5-Methylthiophene
CAS No.	17249-82-0
Molecular Formula	C5H5ClS
Molecular Weight	132.61 g/mol
Synonyms	5-Methyl-2-chlorothiophene; 2-Chloro-5-methylthiophene; 2-Chloro-5-methyl-thiophene; 5-Methyl-2-chloro-thiophene; 2-Chloro-5-methylthiofene; Thiophene, 2-chloro-5-methyl-; 17249-82-0 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methylthiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during long-term storage.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.