Description

3-Hydroxy-Cyclobutanecarboxylic Acid Ethyl Ester is a versatile chiral building block and ester derivative of cyclobutanecarboxylic acid. This compound matters as a key synthetic intermediate for constructing complex molecules with the strained, four-membered cyclobutane ring, which is valuable in medicinal chemistry for modulating physicochemical properties. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery, agrochemical synthesis, and advanced material science.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the cyclobutane ring can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique thermal and mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions of strained systems.
• Flavor & Fragrance Industry: Potential use as an intermediate for synthesizing complex aroma chemicals with unique olfactory characteristics.

Basic Information

Product Name	3-Hydroxy-Cyclobutanecarboxylic Acid Ethyl Ester
CAS No.	17205-02-6
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	Ethyl 3-Hydroxycyclobutanecarboxylate; 3-Hydroxycyclobutanecarboxylic Acid Ethyl Ester; Ethyl 3-Hydroxycyclobutanecarboxylate; 3-Hydroxy-1-cyclobutanecarboxylic Acid Ethyl Ester; Ethyl 3-Hydroxy-1-cyclobutanecarboxylate; 3-Hydroxycyclobutane-1-carboxylic Acid Ethyl Ester; 1-Carboxy-3-hydroxycyclobutane Ethyl Ester; NSC 163022
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for fine chemicals and pharmaceutical intermediates. We implement in-process controls and final release testing, including chiral purity analysis. Certificates of Analysis (COA) are available upon request, detailing parameters such as assay, enantiomeric excess, and impurity profiles. Our quality system supports cGMP and ISO standards for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.