Description

Z-Phe-Gly-Nh2 is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of phenylalanylglycine amide. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), valued for its role in constructing specific peptide sequences with high fidelity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled elongation of peptide chains.
• Pharmaceutical Research: Used in the R&D of therapeutic peptides targeting various metabolic and neurological pathways.
• Bioconjugation: Serves as a linker or spacer molecule in the synthesis of peptide-drug conjugates or labeled peptides.
• Enzyme Substrate Studies: Employed as a synthetic substrate to study protease or peptidase activity and inhibition.
• Chemical Biology Probes: A building block for creating probes to study protein-protein interactions and cellular processes.
• Custom Peptide Production: Essential raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Item	Detail
Product Name	Z-Phe-Gly-Nh2
CAS No.	17187-05-2
Molecular Formula	C19H21N3O4
Molecular Weight	355.39 g/mol
Synonyms	N-Benzyloxycarbonyl-L-phenylalanylglycinamide; Z-L-Phenylalanyl-glycinamide; Cbz-Phe-Gly-NH2; N-Carbobenzoxy-L-phenylalanylglycinamide; Benzyl N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate; Nα-Carbobenzyloxy-L-phenylalanylglycinamide; (S)-2-(((Benzyloxy)carbonyl)amino)-3-phenyl-N-(2-amino-2-oxoethyl)propanamide
EINECS	Contact for details

Quality Control

Our Z-Phe-Gly-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and optical rotation measurement. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.