Description

Triethyl 2-Phosphonobutyrate is a high-purity organophosphorus compound widely utilized as a key building block in organic synthesis. Its primary value lies in its role as a versatile Horner-Wadsworth-Emmons (HWE) reagent, enabling the efficient formation of carbon-carbon double bonds to synthesize complex molecules. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and advanced intermediates.

Application

• As a Horner-Wadsworth-Emmons (HWE) reagent for the stereoselective synthesis of α,β-unsaturated esters and related olefination reactions.
• Key intermediate in the synthesis of pharmaceutical active ingredients (APIs), particularly those containing vinyl phosphonate or butyrate moieties.
• Building block for the research and production of agrochemicals, including herbicides and plant growth regulators.
• Precursor in the manufacture of specialty chemicals and fine chemicals requiring specific phosphonate functionalities.
• Used in material science for the development of flame retardants, plasticizers, and polymer modifiers.
• Valuable reagent in academic and industrial R&D for methodological development in synthetic organic chemistry.

Basic Information

Product Name	Triethyl 2-Phosphonobutyrate
CAS No.	17145-91-4
Molecular Formula	C10H21O5P
Molecular Weight	252.24 g/mol
Synonyms	Diethyl (2-ethoxy-2-oxoethyl)phosphonate; (Carbethoxymethyl)phosphonic Acid Diethyl Ester; Diethyl (carbethoxymethyl)phosphonate; 2-(Diethoxyphosphoryl)acetic Acid Ethyl Ester; Ethyl (Diethoxyphosphoryl)acetate; Acetic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester; Diethyl Phosphonoacetate, Ethyl Ester; EINECS 241-212-1
EINECS	241-212-1

Quality Control

Our Triethyl 2-Phosphonobutyrate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.428 - 1.432
Density (g/mL at 20°C)	1.10 - 1.15

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.