Description

(1R)-2,4,4Aβ,5,6,7,7Aβ,7B-Octahydro-3-Hydroxymethyl-6,6,7Bα-Trimethyl-1H-Cyclobut[E]Indene-1,4α-Diol is a high-purity, stereochemically defined cyclobutane-fused indane derivative. This compound serves as a critical chiral intermediate and building block in advanced organic synthesis, valued for its complex, rigid polycyclic structure. It is primarily utilized by research and development teams in the pharmaceutical and fine chemical industries for the development of novel active compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in steroid-mimetic or complex polycyclic drug candidates.
• Asymmetric Synthesis: Serves as a sophisticated starting material or scaffold for constructing complex molecules with defined stereochemistry in academic and industrial research.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals, fragrances, and advanced materials requiring specific three-dimensional architecture.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value target molecules.
• Chemical Biology Probes: Potential use in the design of molecular probes to study biological systems and enzyme interactions due to its unique structural features.

Basic Information

Product Name	(1R)-2,4,4Aβ,5,6,7,7Aβ,7B-Octahydro-3-Hydroxymethyl-6,6,7Bα-Trimethyl-1H-Cyclobut[E]Indene-1,4α-Diol
CAS No.	16981-75-2
Molecular Formula	C15H24O3
Molecular Weight	252.35 g/mol
Synonyms	(1R,4aS,7aR,7bS)-1,4a-Dihydroxy-3-(hydroxymethyl)-6,6,7b-trimethyl-1,4,4a,5,6,7,7a,7b-octahydrocyclopropa[e]indene; (1R,4aS,7aR,7bS)-3-(Hydroxymethyl)-6,6,7b-trimethyl-1,4,4a,5,6,7,7a,7b-octahydro-1H-cyclopropa[e]indene-1,4a-diol; Cyclobut[e]indene-1,4a-diol derivative; Chiral Cyclobutane-Indane Diol; 16981-75-2
EINECS	Contact for details

Quality Control

Our (1R)-2,4,4Aβ,5,6,7,7Aβ,7B-Octahydro-3-Hydroxymethyl-6,6,7Bα-Trimethyl-1H-Cyclobut[E]Indene-1,4α-Diol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and chemical identity verification, to ensure it meets the stringent requirements for research and process development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.