Description

Roridin E CAS NO 16891-85-3 is a potent macrocyclic trichothecene mycotoxin produced by various *Stachybotrys* and *Myrothecium* fungal species. This compound is of significant interest in biochemical and pharmaceutical research due to its powerful inhibitory effects on eukaryotic protein synthesis. It serves as a critical reference standard and research tool for scientists in toxicology, mycology, and drug discovery, enabling the study of mycotoxin contamination, mechanism of action, and the development of detection methods.

Application

• Analytical Reference Standard: Primary use as a high-purity calibrant for the accurate quantification of Roridin E in environmental, food, and feed samples using HPLC, LC-MS/MS, or ELISA techniques.
• Toxicological Research: Essential for studying the cytotoxicity, immunotoxicity, and specific biochemical pathways (e.g., inhibition of protein synthesis) triggered by trichothecene mycotoxins.
• Mycotoxin Contamination Studies: Used in laboratories to validate analytical methods for detecting *Stachybotrys chartarum* (black mold) and other toxin-producing fungi in buildings, agricultural products, and indoor air.
• Biochemical Probe: Employed in mechanistic studies to understand ribosome function and the cellular stress response to translation inhibitors.
• Pharmaceutical Research: Investigated for its potential as a lead compound or a warhead in antibody-drug conjugates (ADCs) due to its extreme potency.
• Quality Control & Method Development: Serves as a critical component in the development and routine quality control of diagnostic kits and assays for mycotoxin detection.

Basic Information

Product Name	Roridin E
CAS No.	16891-85-3
Molecular Formula	C29H40O9
Molecular Weight	532.62 g/mol
Synonyms	Roridin E; Verrucarin J; 12',13'-Epoxytrichothec-9-ene-3,4,8,15-tetrol, 4,15-diacetate 8-(2-methyl-2-butenoate); (3α,4β,8α)-4,15-Bis(acetyloxy)-12,13-epoxytrichothec-9-en-3,8-diol 8-(2-methyl-2-butenoate); Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(2-methyl-2-butenoate); NSC 167852
EINECS	Contact for details

Quality Control

Our Roridin E is produced and handled under strict quality-controlled conditions to ensure batch-to-batch consistency and high purity, essential for reliable research data. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry guidelines for reference standard materials to support your compliance and research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 2.0 %
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.