Description

Indoline-2-Carboxylic Acid is a versatile heterocyclic building block and chiral synthon of significant importance in advanced organic synthesis. Its constrained bicyclic structure and carboxylic acid functionality make it a critical intermediate for constructing complex molecules with specific stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a precursor for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of protease inhibitors, receptor antagonists, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and insecticides with specific modes of action.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in stereoselective chemical transformations.
• Peptidomimetics Research: Integral for designing and synthesizing conformationally restricted peptide analogs in medicinal chemistry.
• Material Science: Potential monomer or precursor for specialty polymers and functional organic materials.
• Academic & R&D: Serves as a fundamental reagent in university and corporate research laboratories for methodological development and discovery chemistry.

Basic Information

Product Name	Indoline-2-Carboxylic Acid
CAS No.	16851-56-2
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	2-Carboxyindoline; Indoline-2-carboxylic acid; 2-Indolinecarboxylic Acid; (RS)-Indoline-2-carboxylic acid; (±)-Indoline-2-carboxylic acid; 2,3-Dihydro-1H-indole-2-carboxylic acid; 1,2-Dihydroindole-2-carboxylic acid
EINECS	240-870-6

Quality Control

Our Indoline-2-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.