Description

Josamycin CAS NO 16846-24-5 is a macrolide antibiotic belonging to the leucomycin family, valued for its potent antibacterial activity against Gram-positive and some Gram-negative bacteria. It serves as a critical active pharmaceutical ingredient (API) in the formulation of human and veterinary medicinal products. This compound is essential for manufacturers in the pharmaceutical industry, particularly those developing treatments for respiratory tract, skin, and soft tissue infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral dosage forms such as tablets and capsules for human medicine.
• Veterinary Medicine: Formulation into medicated feeds or injectables for treating bacterial infections in livestock and companion animals.
• Clinical Research: Utilized as a reference standard or intermediate in pharmacological and microbiological studies.
• Antibiotic Synthesis: Acts as a key starting material or intermediate for the synthesis of novel macrolide derivatives.

Basic Information

Product Name	Josamycin
CAS No.	16846-24-5
Molecular Formula	C42H69NO15
Molecular Weight	828.00 g/mol
Synonyms	Josamy; Josamina; Josamycinum; Leucomycin V 3-acetate 4''-(3-methylbutanoate); YL-704B3; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-12,13-dihydroxy-7-{[(2R,3S,4S,6S)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-6-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}oxacyclotetradecane-2,10-dione
EINECS	240-873-5

Quality Control

Our Josamycin is manufactured under strict quality management systems. Every batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with comprehensive analysis covering identity, potency, and impurity profiles. A Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.