Description

(3As)-4β,8α-Bis(Acetyloxy)-3Aβ,4,4Aβ,5,6,7,8,8A,9,9Aα-Decahydro-8Aα-Methyl-3,5-Bis(Methylene)Naphtho[2,3-B]Furan-2(3H)-One is a complex sesquiterpene lactone derivative, a class of compounds known for their significant biological activity. This high-purity intermediate is critical for advanced pharmaceutical research and synthesis, particularly in the development of novel therapeutic agents. It is primarily sought by R&D laboratories and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for its utility as a key synthetic building block.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of complex drug candidates, especially those targeting anti-inflammatory or anti-cancer pathways.
• Medicinal Chemistry Research: Used as a scaffold or starting material for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Natural Product Synthesis: Acts as a key intermediate in the total or semi-synthesis of complex natural products and their analogs.
• Biochemical Research: Employed in studies investigating the biological mechanisms of sesquiterpene lactones and their interactions with cellular targets.
• Agrochemical Development: Potential use as an intermediate in the research and development of new crop protection agents with novel modes of action.
• Fine Chemical Synthesis: Utilized in the production of specialty chemicals and high-value, complex organic molecules for various industrial applications.

Basic Information

Product Name	(3As)-4β,8α-Bis(Acetyloxy)-3Aβ,4,4Aβ,5,6,7,8,8A,9,9Aα-Decahydro-8Aα-Methyl-3,5-Bis(Methylene)Naphtho[2,3-B]Furan-2(3H)-One
CAS No.	16822-14-3
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	4β,8α-Diacetoxy-3aβ,4,4aβ,5,6,7,8,8a,9,9aα-decahydro-8aα-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2(3H)-one; 4β,8α-Diacetoxy-3aβ,4,4aβ,5,6,7,8,8a,9,9aα-decahydro-8aα-methyl-3,5-bis(methylene)-2-oxonaphtho[2,3-b]furan; Parthenolide 4,8-Diacetate; Parthenolide Diacetate; 4β,8α-Diacetoxyparthenolide; NSC 106977; 3aβ,4,4aβ,5,6,7,8,8a,9,9aα-Decahydro-4β,8α-bis(acetyloxy)-8aα-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2(3H)-one
EINECS	Contact for details

Quality Control

Our (3As)-4β,8α-Bis(Acetyloxy)-3Aβ,4,4Aβ,5,6,7,8,8A,9,9Aα-Decahydro-8Aα-Methyl-3,5-Bis(Methylene)Naphtho[2,3-B]Furan-2(3H)-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed when not in use to protect from moisture. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Impurity	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.