Description

n-Cbz-4-Hydroxycyclohexane CAS NO 16801-62-0 is a protected hydroxycyclohexane derivative where the hydroxyl group is safeguarded by a carboxybenzyl (Cbz) protecting group. This compound is a critical chiral building block and synthetic intermediate in advanced organic synthesis, particularly for the pharmaceutical industry. It is essential for researchers and manufacturers developing complex molecules, including active pharmaceutical ingredients (APIs) and fine chemicals, where precise stereochemistry and functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the preparation of non-natural amino acid derivatives and peptide mimetics where the cyclohexane scaffold provides conformational rigidity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to construct stereodefined centers.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, agrochemicals, and advanced materials.
• Protecting Group Strategy: The Cbz group allows for selective deprotection under mild conditions, enabling complex synthetic sequences.

Basic Information

Product Name	n-Cbz-4-Hydroxycyclohexane
CAS No.	16801-62-0
Molecular Formula	C₁₄H₁₈O₃
Molecular Weight	234.29 g/mol
Synonyms	4-[(Benzyloxy)carbonyloxy]cyclohexanol; Cyclohexanol, 4-[[(phenylmethoxy)carbonyl]oxy]-; 4-Hydroxycyclohexyl benzyl carbonate; Benzyl 4-hydroxycyclohexyl carbonate; 4-(Benzyloxycarbonyloxy)cyclohexanol; N-CBZ-4-Hydroxycyclohexanol; Z-4-Hydroxycyclohexanol
EINECS	Contact for details

Quality Control

Our n-Cbz-4-Hydroxycyclohexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee (if applicable)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.