Description

3-Chloromethyl-5-Nitrosalicylaldehyde is a versatile and highly functionalized aromatic aldehyde derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a nitro-substituted aromatic aldehyde, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those with antimicrobial or anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Chelating Agent Precursor: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal complexation.
• Dyestuff and Pigment Intermediate: Employed in the production of high-performance, nitro-substituted dyes and organic pigments.
• Polymer Modification: Functional monomer for introducing aldehyde and reactive halogen sites into polymer backbones for specialty resins.
• Cross-coupling Reactions: Valuable substrate in palladium-catalyzed cross-coupling reactions for creating biaryl structures.

Basic Information

Product Name	3-Chloromethyl-5-Nitrosalicylaldehyde
CAS No.	16644-30-7
Molecular Formula	C8H6ClNO4
Molecular Weight	215.59 g/mol
Synonyms	5-Nitro-3-(chloromethyl)-2-hydroxybenzaldehyde; 2-Hydroxy-3-(chloromethyl)-5-nitrobenzaldehyde; 3-(Chloromethyl)-5-nitro-2-hydroxybenzaldehyde; 3-Chloromethyl-5-nitrosalicylaldehyde; 5-Nitrosalicylaldehyde 3-chloromethyl ether (incorrect but common); Salicylaldehyde, 3-(chloromethyl)-5-nitro-; Benzaldehyde, 2-hydroxy-3-(chloromethyl)-5-nitro-
EINECS	240-704-8

Quality Control

Our production of 3-Chloromethyl-5-Nitrosalicylaldehyde adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure consistency and compliance with customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.