Description

(4As)-4Aα,5,6,7,8,8A,9,9Aα-Octahydro-3,8Aβ-Dimethyl-5-Methylenenaphtho[2,3-B]Furan-2(4H)-One is a complex, high-purity sesquiterpene lactone derivative with a unique fused ring structure. This compound serves as a critical chiral intermediate and building block in advanced organic synthesis, particularly for the development of novel pharmaceutical agents and bioactive natural product analogs. It is essential for research and production in pharmaceutical development, agrochemical research, and fine chemical synthesis, where its specific stereochemistry is leveraged to create molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential therapeutic agents, including anti-inflammatory and anticancer compounds.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, exploiting its bioactive sesquiterpene core.
• Fine Chemical Synthesis: Serves as a sophisticated building block for creating complex natural product analogs and specialty chemicals.
• Academic & R&D: A valuable compound for methodological studies in organic chemistry, asymmetric synthesis, and catalysis.
• Fragrance & Flavor Chemistry: Potential use as a starting material for synthesizing unique terpenoid-based aroma chemicals.
• Material Science Research: Investigated as a monomer or precursor for specialized polymers with specific optical or mechanical properties.

Basic Information

Product Name	(4As)-4Aα,5,6,7,8,8A,9,9Aα-Octahydro-3,8Aβ-Dimethyl-5-Methylenenaphtho[2,3-B]Furan-2(4H)-One
CAS No.	16641-51-3
Molecular Formula	C₁₅H₂₀O₂
Molecular Weight	232.32 g/mol
Synonyms	5-Methylene-8a-methyl-3,4,4a,5,6,7,8,8a,9,9a-decahydronaphtho[2,3-b]furan-2(1H)-one; 3,4,4a,5,6,7,8,8a,9,9a-Decahydro-5-methylene-8a-methylnaphtho[2,3-b]furan-2(1H)-one; Parthenolide analog; Sesquiterpene lactone derivative; Decahydronaphthofuranone derivative; 1H-Naphtho[2,3-b]furan-2-one, decahydro-5-methylene-8a-methyl-; (3R,4aS,8aS,9aR)-rel-3,4,4a,5,6,7,8,8a,9,9a-Decahydro-5-methylene-8a-methylnaphtho[2,3-b]furan-2(1H)-one
EINECS	Contact for details

Quality Control

Our (4As)-4Aα,5,6,7,8,8A,9,9Aα-Octahydro-3,8Aβ-Dimethyl-5-Methylenenaphtho[2,3-B]Furan-2(4H)-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral analysis, to ensure identity, purity, and stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity advanced intermediates for research and regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to heat, moisture, and strong oxidizing agents. Keep container tightly sealed when not in use to maintain purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee (by chiral HPLC or GC)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.