Description

Diethyl 2-Fluoro-2-Methyl-Malonate is a high-purity fluorinated malonate ester, a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a gem-dimethyl ester group, makes it an indispensable reagent for introducing fluorinated quaternary carbon centers into target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors who require precise and reliable synthetic intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the introduction of fluorine enhances metabolic stability and bioactivity.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers, liquid crystals, and electronic materials to impart specific chemical resistance or optical properties.
• Organic Synthesis Reagent: Employed in classic malonate chemistry, such as alkylation and condensation reactions, to construct complex, fluorinated carboxylic acids, ketones, and heterocycles.
• Chemical Research & Development: A valuable tool in medicinal chemistry and process chemistry for exploring structure-activity relationships (SAR) and optimizing synthetic routes.

Basic Information

Product Name	Diethyl 2-Fluoro-2-Methyl-Malonate
CAS No.	16519-02-1
Molecular Formula	C8H13FO4
Molecular Weight	192.18 g/mol
Synonyms	Diethyl fluoromethylmalonate; 2-Fluoro-2-methylpropanedioic acid diethyl ester; Fluoromethylmalonic acid diethyl ester; Diethyl (fluoro)methylmalonate; Propanedioic acid, 2-fluoro-2-methyl-, diethyl ester; Ethyl 2-fluoro-2-methylmalonate; Diethyl fluoromethylpropanedioate
EINECS	Contact for details

Quality Control

Every batch of Diethyl 2-Fluoro-2-Methyl-Malonate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including assay (typically >98% by GC/HPLC), identity confirmation (IR, NMR), and impurity profile, is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at controlled room temperature (15-25°C) for shorter periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Specific Gravity (20°C)	1.10 - 1.15
Refractive Index (n20D)	1.410 - 1.420

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.