Description

4-Chloro-7-(Trifluoromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive chloro substituent and a stable, lipophilic trifluoromethyl group, enabling precise molecular construction. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapeutics.
• Agrochemical Synthesis: Used to construct novel herbicides and fungicides, leveraging the bioactivity-enhancing properties of the quinazoline core and CF3 group.
• Material Science Research: Serves as a building block for developing organic electronic materials, such as OLED emitters and charge-transport layers.
• Chemical Biology Probes: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the development of enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	4-Chloro-7-(Trifluoromethyl)Quinazoline
CAS No.	16499-65-3
Molecular Formula	C9H4ClF3N2
Molecular Weight	232.59 g/mol
Synonyms	4-Chloro-7-(trifluoromethyl)quinazoline; 7-(Trifluoromethyl)-4-chloroquinazoline; 4-Chloro-7-trifluoromethylquinazoline; Quinazoline, 4-chloro-7-(trifluoromethyl)-; 16499-65-3; 4-Chloro-7-trifluoromethyl-quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(Trifluoromethyl)Quinazoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.