Description

(R)-(-)-3-Hydroxy-4,4,4-Trichlorobutyric Acid is a high-purity, single-enantiomer chiral building block of significant synthetic utility. This compound matters as a key intermediate for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals where stereochemistry is critical. Industries that require precise chiral synthesis, such as pharmaceutical R&D, fine chemical manufacturing, and advanced material science, are the primary users of this material.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective herbicides and pesticides where biological activity is enantiomer-dependent.
• Fine Chemical Manufacturing: Serves as a versatile building block for creating complex organic molecules in custom synthesis and process development.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new chiral catalysts and synthetic methodologies.
• Material Science: Potential intermediate for synthesizing chiral polymers or liquid crystals with specific optical properties.

Basic Information

Product Name	(R)-(-)-3-Hydroxy-4,4,4-Trichlorobutyric Acid
CAS No.	16493-62-2
Molecular Formula	C4H5Cl3O3
Molecular Weight	207.44 g/mol
Synonyms	(R)-3-Hydroxy-4,4,4-trichlorobutanoic acid; (R)-(-)-3-Hydroxy-4,4,4-trichlorobutyric acid; (R)-3-Hydroxy-4,4,4-trichlorobutanoate; (R)-HTBA; (R)-3-Hydroxy-4,4,4-trichloro-butanoic acid; (3R)-3-Hydroxy-4,4,4-trichlorobutanoic acid; (R)-3-Hydroxy-4,4,4-trichloro-butyric acid
EINECS	Contact for details

Quality Control

Our (R)-(-)-3-Hydroxy-4,4,4-Trichlorobutyric Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Products undergo rigorous analytical testing, including chiral HPLC, NMR, and titration, to meet the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when required for sensitive applications.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.