Description

5-[3-(Diethylamino)-1-Oxopropyl]-10,11-Dihydro-5H-Dibenz[B,F]Azepine CAS NO 16488-05-4 is a high-purity, specialized organic compound belonging to the dibenzazepine class. This chemical is a critical advanced pharmaceutical intermediate valued for its role in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of therapeutic agents.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block in the multi-step synthesis of tricyclic antidepressant and neuroactive drug candidates.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules targeting the central nervous system.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale production for new chemical entities (NCEs) before commercial manufacturing.
• Reference Standard: Supplied as a high-purity compound for analytical method development, validation, and quality control in pharmaceutical laboratories.

Basic Information

Product Name	5-[3-(Diethylamino)-1-Oxopropyl]-10,11-Dihydro-5H-Dibenz[B,F]Azepine
CAS No.	16488-05-4
Molecular Formula	C21H26N2O
Molecular Weight	322.45 g/mol
Synonyms	10,11-Dihydro-5-[3-(diethylamino)propionyl]-5H-dibenz[b,f]azepine; 5-[3-(Diethylamino)propionyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 5-(3-Diethylaminopropionyl)-10,11-dihydro-5H-dibenzo[b,f]azepine; Desipramine Impurity; Desmethylimipramine Related Compound; DMI Intermediate
EINECS	Contact for details

Quality Control

We supply this intermediate under a rigorous quality management system. Each batch is produced and tested to meet exacting standards suitable for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) are provided, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. Our commitment ensures batch-to-batch consistency and traceability for your critical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.