Description

tert-Butyl Methanesulfonate is a versatile alkylating agent and a key organic synthesis intermediate. This compound matters for its role as an efficient tert-butylation reagent, enabling the introduction of the bulky tert-butyl group into target molecules under controlled conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures, developing active pharmaceutical ingredients (APIs), and creating advanced materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly where tert-butyl groups are required for metabolic stability or receptor binding.
• Agrochemical Synthesis: Serves as a building block in the production of herbicides, fungicides, and pesticides that incorporate tert-butyl functionalities.
• Organic Synthesis Reagent: Acts as a powerful alkylating agent in laboratory and industrial-scale organic reactions, including nucleophilic substitutions and esterifications.
• Polymer & Material Science: Employed in the modification of polymers and the creation of specialty monomers to impart specific thermal or chemical properties.
• Ligand & Catalyst Preparation: Utilized in the synthesis of sophisticated ligands and organometallic catalysts for asymmetric catalysis and other advanced chemical processes.
• Fine Chemical Production: A critical intermediate for manufacturing dyes, flavors, fragrances, and other high-value fine chemicals.

Basic Information

Product Name	tert-Butyl Methanesulfonate
CAS No.	16427-41-1
Molecular Formula	C5H12O3S
Molecular Weight	152.21 g/mol
Synonyms	tert-Butyl Methanesulfonate; tert-Butyl Mesylate; Methanesulfonic Acid tert-Butyl Ester; 2-Methyl-2-propyl Methanesulfonate; t-Butyl Methanesulfonate; t-Butyl Mesylate; tert-Butyl Methanesulphonate; 1,1-Dimethylethyl Methanesulfonate
EINECS	240-450-6

Quality Control

Our tert-Butyl Methanesulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. Due to its reactivity as an alkylating agent, appropriate safety measures should be observed.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.05 g/cm³
Refractive Index (n20D)	~1.420 - 1.425

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.