Description

4'-Bromo-2,2,2-trifluoroacetophenone is a versatile and high-value fluorinated aromatic ketone building block. This compound is essential for introducing both bromo and trifluoromethyl functional groups into complex molecular architectures, enabling precise tuning of chemical and physical properties. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl or bromoaryl motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved lipophilicity and target binding.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Serves as a monomer or functionalization agent in the development of fluorinated polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	4'-Bromo-2,2,2-trifluoroacetophenone
CAS No.	16184-89-7
Molecular Formula	C8H4BrF3O
Molecular Weight	253.02 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-bromophenyl)ethanone; 1-(4-Bromophenyl)-2,2,2-trifluoroethanone; p-Bromo-α,α,α-trifluoroacetophenone; 4-Bromo-α,α,α-trifluoroacetophenone; 4'-Bromo-α,α,α-trifluoroacetophenone; 4-Bromophenyl trifluoromethyl ketone; (4-Bromophenyl)(trifluoromethyl)methanone
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and FTIR to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, reducing agents, and heat sources. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.