Description

1-[4-(Tetrahydro-Pyran-2-Yloxy)-Phenyl]-Ethanone is a versatile and high-purity chemical intermediate featuring a protected phenolic hydroxyl group. This compound is critical for synthetic chemists requiring precise control over reactivity in multi-step organic synthesis. It is primarily sought after by the pharmaceutical, agrochemical, and advanced materials industries for the development of active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those requiring selective deprotection and further functionalization.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the tetrahydro-pyranyl (THP) protecting group is essential.
• Organic Synthesis Reagent: Serves as a protected precursor to 4-hydroxyacetophenone, enabling reactions that are incompatible with free phenols.
• Liquid Crystal & OLED Material Research: Acts as a synthetic intermediate for creating novel aromatic compounds used in electronic display technologies.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high-purity aromatic ketones.

Basic Information

Product Name	1-[4-(Tetrahydro-Pyran-2-Yloxy)-Phenyl]-Ethanone
CAS No.	16162-69-9
Molecular Formula	C₁₃H₁₆O₃
Molecular Weight	220.26 g/mol
Synonyms	4'-(Tetrahydro-2H-pyran-2-yloxy)acetophenone; 1-[4-(Oxan-2-yloxy)phenyl]ethanone; 4-Acetylphenyl tetrahydro-2H-pyran-2-yl ether; p-Acetoxyphenyl tetrahydropyranyl ether; THP-protected 4-hydroxyacetophenone; 4-(Tetrahydro-2-pyranyloxy)acetophenone; CAS 16162-69-9
EINECS	Contact for details

Quality Control

Our production of 1-[4-(Tetrahydro-Pyran-2-Yloxy)-Phenyl]-Ethanone adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.