Description

3,5-Bis(Trifluoromethyl)Acetanilide is a high-value, multi-functional fluorinated aromatic intermediate. Its core value proposition lies in the unique reactivity and stability imparted by the two trifluoromethyl groups, making it an essential building block for advanced synthesis. This compound is primarily needed by the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in transition metal catalysis and organocatalysis, enabling novel synthetic transformations.
• Material Science Research: Employed in the creation of fluorinated polymers, liquid crystals, and electronic materials to modify solubility, thermal stability, and dielectric properties.
• Custom Synthesis and R&D: A critical starting material for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis and process development.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Acetanilide
CAS No.	16143-84-3
Molecular Formula	C10H7F6NO
Molecular Weight	271.16 g/mol
Synonyms	N-[3,5-Bis(trifluoromethyl)phenyl]acetamide; 3',5'-Bis(trifluoromethyl)acetanilide; 1-Acetamido-3,5-bis(trifluoromethyl)benzene; Acetamide, N-[3,5-bis(trifluoromethyl)phenyl]-; 3,5-Bis(trifluoromethyl)phenylacetamide
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Acetanilide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.