Description

4-Ethynylphenyl Acetate is a specialized organic building block featuring both an acetyl-protected phenol and a terminal alkyne functional group. This unique bifunctional structure makes it a valuable intermediate for constructing complex molecular architectures via cross-coupling and click chemistry reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel compounds, including potential active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where its alkyne group enables modular structure-activity relationship (SAR) exploration.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, dendrimers, and conductive organic frameworks.
• Click Chemistry: The terminal alkyne moiety is ideal for Huisgen 1,3-dipolar cycloaddition reactions (copper-catalyzed azide-alkyne cycloaddition) for bioconjugation and polymer functionalization.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis and molecular recognition applications.
• Academic & Industrial R&D: A versatile reagent for organic synthesis research in university laboratories and corporate R&D centers exploring new chemical entities.

Basic Information

Product Name	4-Ethynylphenyl Acetate
CAS No.	16141-18-7
Molecular Formula	C10H8O2
Molecular Weight	160.17 g/mol
Synonyms	1-(4-Ethynylphenoxy)ethanone; p-Ethynylphenyl Acetate; 4-Acetoxyphenylacetylene; 4-Ethynyloxyacetophenone; 4-(Acetyloxy)phenylacetylene; 1-Acetoxy-4-ethynylbenzene; (4-Ethynylphenyl) acetate
EINECS	Contact for details

Quality Control

Our 4-Ethynylphenyl Acetate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as scale-up manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.