Description

6-Hydroxy-1-Hexanethiol is a bifunctional organic compound featuring both a terminal thiol (-SH) and a terminal hydroxyl (-OH) group on a six-carbon alkyl chain. This unique structure makes it a versatile building block for synthesizing heterobifunctional linkers, polymers, and surface modifiers. It is particularly valuable for researchers and manufacturers in the pharmaceutical, polymer science, and materials chemistry sectors who require precise molecular control for creating custom architectures.

Application

• Pharmaceutical Intermediates: A key precursor for synthesizing heterobifunctional cross-linkers used in antibody-drug conjugates (ADCs) and targeted drug delivery systems.
• Polymer Modification & Synthesis: Serves as a chain transfer agent (CTA) in controlled radical polymerization (e.g., RAFT) and as a monomer for producing functionalized polymers with pendant thiol or hydroxyl groups.
• Surface Functionalization: Used to create self-assembled monolayers (SAMs) on gold or other metal surfaces, imparting specific chemical functionality for biosensors and biointerfaces.
• Bioconjugation Chemistry: Enables the site-specific coupling of biomolecules (proteins, peptides) to other entities via orthogonal thiol and hydroxyl reactivity.
• Ligand Synthesis for Catalysis: Acts as a starting material for preparing chelating ligands used in homogeneous catalysis and metal complexation.
• Adhesive & Sealant Formulations: Functions as an adhesion promoter and cross-linking agent in specialty epoxy, polyurethane, and silicone systems.

Basic Information

Product Name	6-Hydroxy-1-Hexanethiol
CAS No.	16033-78-9
Molecular Formula	C6H14OS
Molecular Weight	134.24 g/mol
Synonyms	6-Mercapto-1-hexanol; 1-Hexanol, 6-mercapto-; 6-Mercaptohexan-1-ol; 6-Sulfanylhexan-1-ol; Hexane-1,6-dithiol (Note: This is a different isomer); ω-Mercaptohexyl alcohol; Thihexanol; (6-Hydroxyhexyl) mercaptan
EINECS	240-172-6

Quality Control

Our 6-Hydroxy-1-Hexanethiol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep away from strong oxidizing agents and sources of ignition. The container should be kept in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.