Description

Boc-L-Proline CAS NO 15761-39-4 is a high-purity, protected amino acid derivative essential for modern peptide synthesis. It serves as a critical building block for introducing the unique conformational properties of proline into peptide chains while providing orthogonal protection for the amine group. This compound is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries developing novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, stepwise assembly of complex peptides in both research and GMP production.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for drugs targeting cardiovascular, neurological, and metabolic diseases.
• Peptidomimetic Drug Design: Key for creating stable, bioavailable analogs of natural peptides by incorporating proline's rigid, secondary amine structure.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Combinatorial Chemistry Libraries: Employed to generate diverse arrays of compounds for high-throughput screening in drug discovery.
• Agrochemical Research: Used in developing novel peptide-based pesticides and growth regulators.

Basic Information

Product Name	Boc-L-Proline
CAS No.	15761-39-4
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid; N-Boc-L-proline; N-tert-Butoxycarbonyl-L-proline; Boc-Pro-OH; 1-Boc-L-proline; L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-; BOC-L-PRO; N-(tert-Butyloxycarbonyl)-L-proline
EINECS	239-861-4

Quality Control

Our Boc-L-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and optical rotation, to meet exacting customer specifications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and REACH requirements for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-58.0° to -62.0° (c=1 in AcOH)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.