Description

Z-His-4-Nitro-Phe-Phe-Ome is a synthetic, protected tripeptide derivative featuring a histidine (His) residue, a 4-nitrophenylalanine (4-Nitro-Phe) moiety, and a C-terminal methyl ester (Ome). This compound is a crucial building block and intermediate in advanced peptide synthesis and medicinal chemistry research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Protease Inhibitor Research: Used in the design and study of enzyme inhibitors, particularly targeting proteases, due to its modified amino acid sequence.
• Bioconjugation & Labeling: Serves as a scaffold for attaching fluorescent tags, affinity labels, or other functional groups via its reactive nitro group and side chains.
• Structure-Activity Relationship (SAR) Studies: Employed to investigate the impact of specific amino acid modifications (nitration, methylation) on peptide bioactivity and stability.
• Academic & R&D Laboratories: A valuable reagent for fundamental research in organic chemistry, peptide science, and chemical biology.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in peptide analysis.

Basic Information

Item	Detail
Product Name	Z-His-4-Nitro-Phe-Phe-Ome
CAS No.	15574-28-4
Molecular Formula	C₃₃H₃₅N₇O₈
Molecular Weight	657.68 g/mol
Synonyms	Z-His(4-NO₂-Phe)-Phe-OMe; N-Carbobenzoxy-L-histidyl-L-(4-nitrophenylalanyl)-L-phenylalanine methyl ester; CBZ-His-(4-Nitro-Phe)-Phe-OMe; Z-L-His-L-(4-NO₂-Phe)-L-Phe-OMe; Benzyloxycarbonyl-His-(4-nitro-Phe)-Phe-methyl ester; Nα-Cbz-Histidyl-(4-nitrophenylalanyl)-phenylalanine Methyl Ester; Protected Tripeptide Z-His-Phe(4-NO₂)-Phe-OMe
EINECS	Contact for details

Quality Control

Every batch of Z-His-4-Nitro-Phe-Phe-Ome is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), chiral purity, and related substances. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.